by Dr. Peter H Kay
To enable our ancestors to survive much better, nature altered their genetic blueprint so that they could store bodily fat more readily. Stored fat could then be used as a valuable source of energy in times of famine. Now, where food is plentiful, nature’s genetic alteration has become a major health hazard.
Ever since the late 1970s and early 1980s, there has been a gradual and persistent increase in the number of obese subjects in Western societies.
The onset of this increase coincides with the development of sophisticated food refining technologies, suggesting that the availability of cheap highly refined foods with high calorific values contributes significantly to excessive weight gain.
Factors such as lack of exercise and increased food intake have long been considered important mediators of weight gain. These factors, though, cannot tell the complete story because we are all aware of a small number of people who can eat heartily, including processed foods with high calorific content, and yet maintain a healthy body mass index (BMI). Why cannot we all be like those people? Part of the answer lies within our genetic makeup.
Scientists have now discovered that modern man has inherited a common ancestral predisposition to become overweight. So, why is this genetic predisposition to become overweight so common when a lower BMI is associated with better health.
From an evolutionary perspective, it does not make sense. To understand why, we must consider how our genetic blueprint could have adapted over millions of years to enable our ancestors to survive much better.
The story began to unravel about fifty years ago when the scientist Winifred Doane began her search for “famine-survival” genes. In Nigeria, she found some unusually fat flies that had managed to survive in adverse conditions. In the laboratory, she discovered that the fat flies had a poorly acting form of a gene she called adipose (ADP).
Since then, the ADP gene has been found in many different species see Ref. 1 and references therein. Reduced activity of the ADP gene has been shown to lead to fat accumulation in all species studied. In 2003, the ADP gene was discovered in humans 2.
A few years later, scientists at Tufts University discovered that most of us have inherited a sluggish ADP gene that slows down the way that fat it is burnt off or turned into energy 3. It also enables fat to be stored in our tissues more easily so that we gain weight. So, where did our sluggish ADP gene come from?.
It is now thought that our inefficient ADP gene originated millions of years ago and, over time, increased in frequency because it gave our ancestors an important survival advantage. The less effective fat metabolising gene was of benefit because what little food was available was easily laid down and stored as fat deposits.
Fat deposits could then be used as a source of energy and help survival in times of famine. Those who carried an efficient fat metabolising ADP gene and who could not store fat so well would have been more likely to perish in times of famine. That is why an efficient ADP gene is so uncommon now.
Interestingly, the sluggish ancestral ADP gene, even though it predisposes to ill-health, is in fact, considered normal because it is the most common form of the ADP gene.
In modern times though, in areas of the world where, for the first time in human history, refined food is plentiful, the common ancestral ADP gene has become a health problem because it continues to store our food as fat, resulting in obesity and increased susceptibility to development of diseases such as diabetes and heart disease.
In fact, it has been suggested that the sluggish ADP gene is directly responsible for development of late onset diabetes associated withobesity
It follows that increasing the efficiency of the common ancestral ADP gene would be an effective way to lose weight, reduce fat deposition, maintain a healthy BMI and to avoid development of many diseases.
Homeovitality Super Weight-Loss product, the health supplement developed in Australia by the world renowned molecular geneticist Dr. Peter H. Kay has been scientifically formulated to do exactly that. Homeovitality is based on the proven drug free gene targeting principles of New Homeopathy, developed by Dr. Marichal, in which immune response genes are targeted by highly diluted DNA molecules.
Everyone who has inherited the common ancestral ADP gene would benefit from taking the Homeovitality Super Weight Loss health supplement on a permanent basis. It can be obtained via eBay and searching under “homeovitality” or online by visitingwww.homeovitality.co.uk
The author can be contacted on [email protected]
1. Suh J.M. et al., Adipose is a conserved dosage-sensitive antiobesity gene. Cell. Metab., 6:195-207, 2007.
2. Hader T., et al., Control of triglyceride storage by a WD40/TPR-domain protein. EMBO Rep. 4:511–516, 2003.
3. Lai C.Q. et al., WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. Obesity, 17: 593–600, 2009.