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Genetics and the Causes of Obesity

Causes of obesity

Several countries have unfortunately earned themselves the nickname ‘the super-size nation.’ America, the UK and parts of western Europe are fat and getting fatter. Waistlines are expanding beyond the limits of the clothes they are contained in. Poor diet, lack of exercise and a couch potato lifestyle are some of the possible contributory reasons. But wait a minute, that’s not the full picture.

For some people there is almost certainly a genetic component, and with the many health problems related to obesity, scientists are feverishly working in their labs trying to answer some very big questions. Is there an obesity gene? What are the genetics of obesity? The research on obesity genes is a very active area.

Obesity and genes

Maria De Luca and colleagues at the University of Alabama in Birmingham have made a valuable contribution to the field with their work on the humble fruit fly, Drosophila melanogaster. Although it’s not really a creature known for tipping the scales, there are many similarities in the way human and fruit fly synthesise and regulate fat.

The researchers identified 4 candidate genes in fruit flies and one in particular, Laminin A (Lan A) that is associated with body weight and triglyceride storage (dietary fat is synthesised into triglycerides). This gene is similar to human LAMA5 which sits on chromosome 20.

They looked at 3 different variations of the gene in humans to see if they could spot a correlation between the gene variants and variants in body shapes. In other words, do natural variations in the LAMA5 gene play a key role in determining weight?

Results

228 women took part in the study. So what did the researchers uncover? As reported in the journal BMC Genetics they discovered that two of the gene variants were associated with body shape. One with women of European American descent and the other in women of African American descent.

As De Luca observed. “We found one variant to be associated with weight and lean mass in both ethnic groups. This variant was also associated with height, total fat mass and HDL-cholesterol, but only in European American women. A different variant was associated with triglyceride levels and HDL-cholesterol level in African American women.” In fact in one of the variants was associated with higher weight in African American women

Future obesity research

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